Fig. 7: PI3K-driven cancers are sensitive to the erwinase-temsirolimus combination.
From: A metabolic synthetic lethality of phosphoinositide 3-kinase-driven cancer
A Pearson correlation between the difference of cytotoxicity of L-asparaginase (either erwinase – left or kidrolase – right) and temsirolimus minus the effect of L-asparaginase alone (∆ cytotoxicity) and the ZIP synergy score of the combination. B Pearson correlation between the ∆ cytotoxicity and the ZIP synergy score of erwinase-temsirolimus stratified by cancer type. C ZIP synergy score of the combination of erwinase/temsirolimus (top) or kidrolase/temsirolimus (bottom) in the tested cancer models. D Cytotoxicity of erwinase (Erw), temsirolimus (Tem), kidrolase (Kid), or their combination on the broad array of either wild-type PI3K (blue) or PI3K-altered (red) solid cancer cell lines. Significative differences in cell viability relative to control are indicated by a black dot. A two-way ANOVA test adjusted for multiple comparisons (Dunn–Šidák correction) was computed.
