Fig. 1: SARS-CoV-2 infection causes lung function and metabolic changes that are exacerbated by exercise in aged hamsters. | Nature Communications

Fig. 1: SARS-CoV-2 infection causes lung function and metabolic changes that are exacerbated by exercise in aged hamsters.

From: Respiratory long COVID in aged hamsters features impaired lung function post-exercise with bronchiolization and fibrosis

Fig. 1

a Left panel: relative body weight (% starting body weight) of SARS-CoV-2 and mock-infected hamsters over time. Right panel: total clinical score (including weight loss, respiratory, and behavioral signs) of SARS-CoV-2 and mock-infected hamsters over time. Data was collected daily until 21 days post infection (dpi) and weekly from 21 to 112 dpi. b Results of whole-body plethysmography (WBP) measurements from 0 to 14 dpi without exercise prior to the measurement. First row: frequency (f) expressed in breaths per minute (BPM), tidal volume (TV), mid-tidal expiratory flow (EF50), expiration time (Te), and inspiration time (Ti). Second row: volume of O2 uptake (vO2), CO2 production (vCO2), metabolic rate (MR), and respiratory quotient (RQ). c Results of WBP measurements from 21 to 112 dpi. Upper two rows: measurements taken before exercise. Lower two rows: measurements taken immediately after exercise on a rodent treadmill (10 minutes with accelerating speed starting at 10 m/min and ending at 15 m/min at a 5° upward slope). Graphs show mean and standard error of the mean (SEM). Data from WBP measurements were tested by a Wilcoxon test. A p value of ≤0.05 was chosen as the cutoff for statistical significance. a, b N = 56 (0–1 dpi), 48 (2–3 dpi), 40 (4–6 dpi), 32 (7–14 dpi), 24 (15–28 dpi), 16 (29–56 dpi), or 8 (57–112 dpi) animals/group. c N = 18 (0–28 dpi), 12 (29–56 dpi) or 6 (57–112 dpi) animals/group. Source data are provided as a Source Data file.

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