Fig. 3: Bulk RNA-sequencing analysis reveals the presence of distinct DEGs in the sub-acute and chronic phases of the disease. | Nature Communications

Fig. 3: Bulk RNA-sequencing analysis reveals the presence of distinct DEGs in the sub-acute and chronic phases of the disease.

From: Respiratory long COVID in aged hamsters features impaired lung function post-exercise with bronchiolization and fibrosis

Fig. 3

a UpSet plot of unique differentially expressed genes (DEGs) and overlapping DEGs at different days post infection (dpi) from the sub-acute and chronic phases (14, 28, 56, 112 dpi). The total number of DEGs associated with each dpi is depicted in the colored histogram to the left. The scheme below the boxplots depicts unique or overlapping numbers of DGEs at a given dpi. Connected dots represent DEGs shared by two or more dpi. The number of unique or overlapping DEGs is shown on the top of the bars. b–d Cluster profiler of EnrichGO pathway analysis for unique DEGs at 14, 28, 56 dpi shown in the Upset plot. The y axis shows the enriched pathways, and the x axis shows the GeneRatio (gene-count/total number of genes). Dot size indicates the number of genes and color change indicates the p value.

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