Fig. 2: African-specific PP-SVs disrupting well-known pathogenic cancer genes and/or PCa tumour suppressor genes, including DNA damage response genes. | Nature Communications

Fig. 2: African-specific PP-SVs disrupting well-known pathogenic cancer genes and/or PCa tumour suppressor genes, including DNA damage response genes.

From: Rare pathogenic structural variants show potential to enhance prostate cancer germline testing for African men

Fig. 2

A 4877 base pLoF deletion on DNA damage repair gene BARD1. B pLoF INV impacting PCa DNA mismatch repair gene MLH1. C pLoF INV impacting PCa tumour suppressor RB1. D pLoF INV impacting PCa tumour suppressor gene WASF1. E pLoF INV impacting PCa tumour suppressor gene FOXP1. More details of SV region and/or breakpoints on impacted genes and visual inspection of sequencing reads using Integrative Genomic Viewer51 are shown in Supplementary Figs. 8, 12, 13, 14 and 15, respectively.

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