Fig. 7: LiCl impacts brain growth and metabolism pathways.
From: Neuron-specific isoform of PGC-1α regulates neuronal metabolism and brain aging
A Venn diagram of significant genes detected in the brains of mice treated with 4 different doses of LiCO3 compared to control mice (n = 4 mice/ diet). B Venn diagram of pathways enriched in the brains of mice given 1.2, 1.8, and 2.4 g/kg/day. Pathways were detected by PathfindR. C Heatmap of the 56 genes that are differentially expressed in all 3 doses. D Heatmap of 53 overlapping enriched pathways detected by PathfindR. E–G Dotplots of top 5 enriched pathways in the 1.2 (E), 1.8 (F) and 2.4 (G) g/kg mouse brains. Significant pathways were determined by an FDR < 0.05. H, I Heatmap of the significantly changing genes in MAPK Signaling (H) and Circadian Rhythm (I) pathways across each of 3 doses of LiCO3. J Table displaying common KEGG pathways between the 30v10 30v20 and the LiCO3 diets comparison. An up arrow indicates positively enriched in 30 months compared to 10 or 20 months, respectively, or in LiCO3 diets compared to the control diet.
