Fig. 6: Alteration in CRC immune microenvironment after CAA-PEG NSs treatment in vivo.
From: In situ valence-transited arsenic nanosheets for multi-modal therapy of colorectal cancer
a The percentages of DC maturation in tumors following different treatments (gated on CD11c+ DC cells). b The percentages of tumoral CD4+ and CD8+ T cells following various treatments (gated on CD3+ T cells). The cytokines secretion of TNF-α (c) IFN-γ (d) and IL-1β (e) in serum following various treatments. The percentages (f) and statistical analysis (g) of M1 and M2 TAMs after different treatments (gated on F4/80 macrophages). h Immunofluorescent staining (M1-CD86) of tumor sections after different treatment. i The cytokine secretion of IL-6 and IL-10 in serum following different treatments. The gating strategy is presented in Fig. S10. For all figures here, data are presented as mean values +/− SD, n = 3 mice. One-way ANOVA with Tukey’s Multiple Comparison Test was used to compare the mean of each group with the mean of the Control group. P values were presented in absolute value in the figures.
