Fig. 4: Differential expression of gene signatures between TNBC vs. ER+ anti-PD-1 treated breast cancers. | Nature Communications

Fig. 4: Differential expression of gene signatures between TNBC vs. ER+ anti-PD-1 treated breast cancers.

From: Dissecting tumor cell programs through group biology estimation in clinical single-cell transcriptomics

Fig. 4

a Schematic showing the comparison groups—TNBC vs. ER+ anti-PD-1 treated breast cancers. b UpsetPlot depicting the overlap between differentially expressed gene signatures identified by BEANIE, MWU-BH, GLM, pseudobulk and their LOOCV variants, across tumor states. c Upsetplot showing the gene signatures differentially expressed across tumor cell states or within an individual tumor state. d Dotplot showing the gene signatures enriched across tumor cell states (shared among two or more tumor states). e Barplot depicting examples of differentially expressed gene signatures with biological relevance identified by BEANIE for each of the tumor states (*** indicates p values < 0.0001).

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