Fig. 6: Liver fibrosis modifies the distribution of gene transfer within the liver lobule.
From: Liver fibrosis negatively impacts in vivo gene transfer to murine hepatocytes
a, b Representative images of zonation analysis, based on immunofluorescence staining of liver sections from control mice administered with LV.mCherry. Gray circles indicate the analyzed periportal (a) or pericentral (b) areas. a Anti-mCherry antibody (red), anti-CK7 antibody (yellow), and periportal area (gray). b Anti-mCherry antibody (red), anti-GS antibody (yellow), and pericentral area (gray). c, d Violin plot with individual values, median, and quartiles of the fold between periportal (PP) over pericentral (PC) mCherry-positive liver area of mice treated with LV.mCherry (c) or AAV.mCherry (d) (Wilcoxon signed-rank test against 1, Kruskal–Wallis test, or Mann–Whitney test between test and control groups). The dotted line represents fold = 1. Row data are displayed in Supplementary Fig. 7. Source data are provided as a Source Data file.
