Fig. 1: Lateral flow immunoassay signal amplification with DNA origami.
From: DNA origami signal amplification in lateral flow immunoassays
Structurally precise DNA nanostructures are prepared with the DNA origami self-assembly method. The DNA origami is applied as an adapter that connects a specified, low number of detection antibodies to multiple labels. The greatly enhanced number of labels per antibody and per bound analyte at the test line leads to a stronger signal and makes lower analyte concentrations detectable by the naked eye.
