Fig. 6: Enrichment of functional annotations at putative parent-of-origin allele-specific regions.
From: Atlas of imprinted and allele-specific DNA methylation in the human body
A Percent of parental ASMs annotated as active promoters and bivalent enhancers (chromHMM TssA and EnhBiv terms, respectively). B Enrichment of gene regulatory activity, based on H3K27ac peak annotation in 387 ChIP-seq experiments (AREs)53. C Enrichment for Polycomb repressive regions (chromHMM ReprPC). D Local enrichment for origins of replication, identified using peaks of nascent strand DNA (left), as well as early replication, measured as the ratio of S to G1 phase DNA fragments53. E Enrichment of parental-ASM regions with allelic difference in S/G1 ratio at heterozygous sites53.
