Fig. 3: Costimulatory blockade restricts Tfr clonal expansion. | Nature Communications

Fig. 3: Costimulatory blockade restricts Tfr clonal expansion.

From: Follicular regulatory T cells restrain kidney allograft rejection in mice by suppressing alloreactive B cells

Fig. 3

a Clonal expansion indicated in UMAP space utilizing scRepertoire. Each dot represents an individual cell, with colors indicating the size of clonal expansion. Pink indicates singleton clones, while dark pink and red indicate small (1<x < =5) and medium (5<x < =20) clonal expansion, respectively. b Distribution of clonal expansion across experiment groups (left) and clusters (right). c Correlation of clonal expansion and sharing of clones between Tfr and Treg cells calculated by scRepertoire. Circled clones indicate shared clones. d Proportion of clonal sharing between cluster 0 and other clusters, with cluster 0 set as founder clones. The thickness of lines indicates magnitude of shared clones. e Circos plot showing sharing of expanded clones between clusters. Only expanded clones are included.

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