Table 4 Characteristics for screening-detected cancer according to general radiologist with or without the use of AI

From: Artificial intelligence for breast cancer screening in mammography (AI-STREAM): preliminary analysis of a prospective multicenter cohort study

No

GRs with AI (A)

Proportion (95% CI)

GRs (B)

Proportion (95% CI)

AI standalone (C)

Proportion (95% CI)

Difference (95% CI)

p-value

A vs B

A vs C

B vs C

A vs B

A vs C

B vs C

Cancer, detection

120

 

95

 

128

       

 DCIS

  39

83 (72.2, 93.7)

  33

70.2 (57.1, 83.3)

  41

87.2 (77.7, 96.8)

−12.8 (−22.3, −3.2)

4.3 (−4, 12.5)

17 (4.8, 29.3)

0.009

0.312

0.006

 Invasive cancer

  81

80.2 (72.4, 88)

  62

61.4 (51.9, 70.9)

  87

86.1 (79.4, 92.9)

−18.8 (−27.8, −9.8)

5.9 (0.6, 11.3)

24.8 (15.1, 34.4)

<0.001

0.030

<0.001

Sizea

79

 

63

 

84

       

 <20 mm

  46

76.7 (66, 87.4)

  37

61.7 (49.4, 74)

  52

86.7 (78.1, 95.3)

−15 (−26.1, −3.9)

10 (2.4, 17.6)

25 (13.1, 36.9)

0.008

0.010

<0.001

 ≥20 mm

  33

82.5 (70.7, 94.3)

  26

65 (50.2, 79.8)

  32

80 (67.6, 92.4)

−17.5 (−31.2, −3.8)

−2.5 (−7.3, 2.3)

15 (0.2, 29.8)

0.012

0.311

0.047

Lymph nodea

72

 

56

 

75

       

 Negative

  58

77.3 (67.9, 86.8)

  44

58.7 (47.5, 69.8)

  61

81.3 (72.5, 90.2)

−18.7 (−29.6, −7.8)

4 (−1.8, 9.8)

22.7 (11.2, 34.1)

0.001

0.174

<0.001

 Positive

  14

93.3 (80.7, 100)

  12

80 (59.8, 100)

  14

93.3 (80.7, 100)

−13.3 (−30.5, 3.9)

0

13.3 (−3.9, 30.5)

0.129

NA

0.129

IHC type of IDCa

58

 

44

 

63

       

 Luminal A

  40

71.4 (59.6, 83.3)

  30

53.6 (40.5, 66.6)

  45

80.4 (70, 90.8)

−17.9 (−31.1, −4.7)

8.9 (1.5, 16.4)

26.8 (13.2, 40.3)

0.008

0.019

<0.001

 Non-luminal A

  18

100 (100, 100)

  14

77.8 (58.6, 97)

  18

100 (100, 100)

−22.2 (−41.4, −3)

0

22.2 (3, 41.4)

0.023

NA

0.023

Subtype of IDCa

94

 

83

 

87

       

 IDC NOS

66

 

43

 

60

       

  Grade I

  14

60.9 (40.9, 80.8)

 8

34.8 (15.3, 54.2)

  16

69.6 (50.8, 88.4)

−26.1 (−50.8, −1.3)

8.7 (−2.8, 20.2)

34.8 (11.9, 57.7)

0.039

0.139

0.003

  Grade II

  28

82.4 (69.5, 95.2)

  23

67.6 (51.9, 83.4)

  29

85.3 (73.4, 97.2)

−14.7 (−29.1, −0.3)

2.9 (−2.7. 8.6)

17.6 (2.5, 32.8)

0.046

0.310

0.023

  Grade III

  15

93.8 (81.9, 100)

  12

75 (53.8, 96.2)

  15

93.8 (81.9, 100)

−18.8 (−37.9, 0.4)

0

18.8 (−0.4, 37.9)

0.055

>0.99

0.055

   Unkown grade/ILC/Special type

16/6/2

11/6/2

18/7/2

 
  1. All p-values were two-sided, and p-value < 0.05 indicates statistical significance.
  2. Non-luminal A: luminal B, HER2 (Human epidermal growth factor receptor-2) enrich, triple negative.
  3. GRs general radiologists, AI artificial intelligence, DCIS ductal carcinoma in situ, IDC invasive ductal carcinoma, NOS not otherwise specified, IHC immunohistochemistry.
  4. aNumbers for available results.
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