Fig. 5: BE(-ST)@siBACE1 therapy improves cognitive function in APP/PS1 mice. | Nature Communications

Fig. 5: BE(-ST)@siBACE1 therapy improves cognitive function in APP/PS1 mice.

From: Berberine-inspired ionizable lipid for self-structure stabilization and brain targeting delivery of nucleic acid therapeutics

Fig. 5

a Experimental timeline showing treatment regimen of APP/PS1 and wild-type (WT) mice receiving tail vein injections of LNP@siBACE1 or PBS every 2 days for seven cycles, followed by Morris water maze (MWM) testing and tissue collection. b–e MWM probe test results: b Representative swimming trajectories during platform search. c Time spent in target quadrant as percentage of total time. d Platform location crossing frequency. e Mean swimming speed across groups. Data are presented as mean ± SD (n = 6 biologically independent animals). Statistical significance was determined by two-tailed unpaired Student’s t test; *P < 0.05, **P < 0.01, ***P < 0.001. Source data are provided as a Source Data file.

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