Fig. 1: Magnetic Janus hydrogel microrobots for the regeneration of gradients in the TBI.
From: Janus hydrogel microrobots with bioactive ions for the regeneration of tendon-bone interface
A Equipment and fabrication of magnetic Janus hydrogel microrobots by gas shearing. B Motion behavior of the microrobots under an external magnetic field. C Application of the microrobots in RCT reconstruction surgery. D Therapeutic effect and underlying mechanism of the microrobots in the regeneration of gradients in the TBI. Through rebuilding of the Mg2+/Zn2+ mineral gradient, spatiotemporally modulating the cell phenotypes of BMSCs and TCs, synchronously regenerating bone and tendon, and restoring the gradient tendon‒bone transition structure of the TBI, microrobots eventually promote TBI healing. MgP: Mg3(PO4)2, Fe-NPs: Fe3O4 nanoparticles, Zn-NPs: ZnO nanoparticles, BMSCs: bone mesenchymal stem cells, TCs: tenocytes. Created in BioRender. Ding, Z. (2025) https://BioRender.com/p43d624.
