Fig. 6: High tumor SPD level and expression of MEPO signature predicts a poor prognosis.
From: Methionine metabolite spermidine inhibits tumor pyroptosis by enhancing MYO6-mediated endocytosis
(A) SPD level is evaluated by IHC staining in 220 NPC tumor tissues. Scale bar: 100μm. (B) Association between SPD level and death status in a cohort of 220 NPC samples (two-sided χ2 test). (C) Kaplan–Meier analysis of overall survival based on the SPD level (log-rank test). (D) The correlation between MEPO signature expression and activated DC signature expression in head and neck squamous carcinoma (HNSC), lung adenocarcinoma (LUAD) and esophageal carcinoma (ESCA) (The correlation coefficient and two-tailed p value were calculated using Pearson’s correlation analysis). (E) The correlation between MEPO signature expression and effector T cell signature expression in HNSC, LUAD and ESCA (Pearson’s correlation analysis). (F) Kaplan–Meier analysis of overall survival based on the SPD level in HNSC, LUAD and ESCA (log-rank test). Source data are provided as a Source Data file.
