Fig. 7: The polycystin complex, PACL-1, and the PAMLs act in the same genetic pathway.
From: Polycystins recruit cargo to distinct ciliary extracellular vesicle subtypes in C. elegans
a A diagram showing steps in the male mating behavior controlled by the polycystin pathway—response to hermaphrodite and vulva location. b Assessment of male mating behavior shows that the pacl-1 mutant is deficient in responding to hermaphrodite contact. Number of mating trails conducted were: n = 6 WT, 3 pacl-1(tm12580), 5 pkd-2(sy606), and 3 pacl-1(tm12580)rescue. Vulva location behavior of the pacl-1 mutants could not be assessed due to their severe response defect. Assessment of male mating behavior shows that the paml-1; paml-2 double mutant is deficient in responding to hermaphrodite contact (c), and location of vulva (d, e). Number of mating trails conducted were: n = 8 WT, 3 paml-1(tm12527), 3 paml-2(my155), and 8 paml-1(tm12527); paml-2(my155) double mutant. 20 adult males were tested in each mating trial. Bar graphs represent mean values +/- SD. One-way ANOVA analyzed data with the Tukey post hoc adjustment. Source data are provided as SourceData_Main.xls file.
