Fig. 9: Proteomic quantitative analysis to explore the antitumor mechanism of EcN@INX-2.

a Biological processes, cellular components, and molecular functions of diverse proteins were scrutinized through GO term enrichment analysis (n = 3 mice). b Bar charts representing the distinct proteins associated with the specific biological process of interest, as characterized by GO annotations (n = 3 mice). c Heat map showing top 30 highly expressed proteins. Statistical analyzes were performed using two-tailed Student’s t-test. Box, median with whiskers at minimum and maximum values (fold change ≥ 2 or fold change ≤ 1/2, P < 0.05) (n = 3 mice). d Venn diagram delineated the distinct biological processes associated with heat shock and oxidative stress, as well as the intersecting biological processes related to bacterial infection, inflammatory response, and immune response (n = 3 mice). e The PPI of the top 25 differentially expressed proteins (n = 3 mice). Source data are provided as a Source Data file.