Fig. 2: Structural features of the Mip1-DNA complex.
From: Structural basis for intrinsic strand displacement activity of mitochondrial DNA polymerase
A Mip1 surface charge distribution. B Schematic representation of Mip1-DNA interactions in Structure I. Residues are color-coded to match the corresponding structural elements. Non-template and template DNA bases, for which density is missing in Cryo-EM maps, are shaded. Polγ residues corresponding to the key residues of Mip1 involved in strand displacement are shown in parentheses. C Structural comparison of Mip1 (Structure I) with human Polγ-A. The enzymes are aligned using their conserved palm domain. The Catcher loop in human Polγ is modeled using AlphaFold3. D Major interactions of Mip1 with DNA. E A close-up view of the pol active site of Mip1 shown with Coulombic density (blue mesh). The incoming nucleotide, dATP, is in yellow.
