Fig. 1: GCN5 is highly expressed in high-grade gliomas. | Nature Communications

Fig. 1: GCN5 is highly expressed in high-grade gliomas.

From: GCN5-targeted dual-modal probe across the blood-brain barrier for borders display in invasive glioblastoma

Fig. 1

a Heatmap clustering shows a significant positive correlation between GCN5 expression and glioma pathological grade, tissue type, patient age, and IDH mutation status, based on Chinese Glioma Genome Atlas (CGGA) database analysis. b GCN5 expression levels, derived from 749 glioma samples in the CGGA database, are significantly elevated in World Health Organization (WHO) grade IV GBMs compared to lower-grade gliomas.WHO grade II, n = 218 samples (blue); WHO grade III, n = 240 samples (red) and WHO grade IV, n = 291 samples (green). c Representative immunohistochemistry (IHC) images illustrating GCN5 expression in normal brain tissue, low-grade gliomas, and high-grade gliomas. d Comparison of GCN5 expression levels in WHO grade II and grade IV gliomas. WHO grade II, n = 36 samples (blue); WHO grade IV, n = 51 samples (red). The data (b) and (d) are presented as box - plots and the data distribution characteristics are shown through violin plots. The upper and lower bounds of the box are defined by the 75th and 25th of the data distribution. The median is represented by a bold horizontal line within the box. The whiskers above and below the box are the maximum and minimum values. The P value in (b and d) was calculated by the two-sided Mann-Whitney U test (Wilcoxon rank-sum test). ****p < 0.0001.

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