Fig. 3: Biocompatibility evalution of ICG-Gd-Den@DC-G16-11. | Nature Communications

Fig. 3: Biocompatibility evalution of ICG-Gd-Den@DC-G16-11.

From: GCN5-targeted dual-modal probe across the blood-brain barrier for borders display in invasive glioblastoma

Fig. 3

a Cytotoxicity of U87 cells, CHG5 cells and HEB cells under 150 μg mL-1 concentrations of ICG-Gd-Den@DC-G16-11 (n = 3 independent experimental replicates). b Blood chemistry examinations. Globulin (GLOB), albumin (ALB), plasma alkaline phosphatase (ALP), alanine aminotransferase (ALT), and aspartate aminotransferase (AST), total bilirubin(T-BIL), total protein (TP), uric acid (UA), blood urea nitrogen (BUN), creatinine (CRE) levels were assessed after tail vein injection of physiological saline, ICG-Gd-Den@DC-G16-11 and ICG-Gd-Den (100 μL of 20 mg mL-1, Gd concentration: 1.5 mg mL-1). n = 3 independent experimental replicates. c H&E staining images of main organs (heart, liver, lung, spleen, and kidney) from each group. Data in (a, b) are presented as mean values ± SD.

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