Fig. 5: Dissect the enhanced polygenicity for GIANT.
From: A genetically informed brain atlas for enhancing brain imaging genomics
GIANT defined brain regions yield enhanced discovery power compared to MUSE. In this example, we present the GWAS results for left central operculum (MUSE 113) and left composite of central operculum, anterior insula, and posterior insula regions (GIANT 16). We observed that some GWAS loci were detected to be significant in GIANT 16 that did not reach the significant threshold in MUSE 113 (circled by dashed red rectangles) and some of the GWAS loci yield more significant p values in GIANT 16 than in MUSE 113 (circled by dashed green rectangles). GIANT Genetically informed brain atlas, MUSE ensemble multi-atlas, GWAS genome-wide association study.
