Fig. 7: Genetic architecture of GIANT.

We conducted a comprehensive assessment of the genetic architecture of GIANT through a multifaceted approach. a We investigated the relationships between GIANT regions and other phenotypic traits. We reported only those traits in the NHGRI-EBI GWAS Catalog that have significant overlapping GWAS signals. The GIANT regions are color-coded based on their sub-structures, and each region and trait are labeled by the proportion of their shared significant GWAS hits out of the total number of significant GWAS signals. b We annotated the functional significance of SNP variants. We counted the number of regions with significant GWAS signals that were functionally annotated in various genome regions. The GIANT regions were color-coded based on their sub-structures. c We conducted a comparison of pairwise regional genetic and phenotypic correlations, with the genetic correlations presented in the lower-left triangular regions and the phenotypic correlations located in the upper-right regions. The GIANT regions were grouped and color-coded based on their sub-structures. GIANT genetically informed brain atlas, DEEP_WM_GM deep structure of white matter and gray matter, NONE others, GWAS genome-wide association study, UTR5 5’ untranslated region, UTR3 3’ untranslated region, upstream upstream regulatory region, downstream downstream regulatory region, ncRNA non-coding RNA.