Table 1 Comparison with other metal predictors
Predictor | Category | Input data | Method | Output data | Type and number of ligands | Provide metal ion location | Provide a structural model | Typical response time | Year of publication |
|---|---|---|---|---|---|---|---|---|---|
PMM | III | Structure, Uniprot ID | Geometry, ML | PDB file, Structure | CHED ≥ 2 | Yes | Yes | 5–50 s | 2023 |
Metal3D | II | Structure | CNN | Zinc ion location | N/A | Yes | No | 3-60 min | 2023 |
AlphaFill | II | Structure, Uniprot ID | Structure homology | PDB file, Structure | N/A | Yes | Yes | 5–50 s | 2023 |
ZincBindDB | I | Structure, Sequence | ML | Predicted sites | CHED ≥ 2 | No | No | 3-10 min | 2021 |
znMachine | I | Sequence | ML | Predicted sites | CHED ≥ 3 | No | No | Unavailable | 2019 |
GRE4Zn | III | Structure | Geometric restriction | PDB file | CHED ≥ 3 | Yes | No | 5–30 s | 2014 |
TEMSP | III | Structure | ML | PDB file | CHED ≥ 3 | Yes | No | Unavailable | 2011 |
CHED | I | Structure | ML | Predicted sites | CHED | No | Yes | Unavailable | 2007 |
