Fig. 4: Differential expression of immune modules in SARS-CoV-2 infection by symptom presence.
From: Age-associated differences in mucosal and systemic host responses to SARS-CoV-2 infection
Heatmaps depict results of gene set enrichment analysis of upper respiratory (children and adolescents) and peripheral blood (children, adolescents, and adults) bulk RNA sequencing data comparing gene expression among SARS-CoV-2-infected participants who reported a symptom to infected participants who did not report that symptom. Each column corresponds to a gene module comprised of co-expressed genes that share a similar function. The numbers within blocks represent normalized enrichment scores (NES) for comparisons of gene module expression that were statistically significant (padj < 0.05). The color of each block indicates the direction of the change in expression (red, upregulated in the condition of interest; blue, downregulated in the condition of interest). Analyses were adjusted for age group, sex, sequencing batch, and imputed sample immune cell proportions (peripheral blood only). Source data are provided as a source data file. (TNF tumor necrosis factor; NK natural killer; Treg regulatory T).
