Fig. 5: Clusters of stroke lesions pre and postsynaptic ratios.
From: Neurotransmitters’ white matter mapping unveils the neurochemical fingerprints of stroke
a Training set. The sample sizes for clusters 1 to 8 are, respectively, 255, 89, 96, 452, 87, 121, 67, and 166. b Validation set. The sample sizes for clusters 1 to 8 are, respectively, 32, 18, 5, 39, 10, 19, 2, and 18. Ratios are presented in a natural logarithmic scale. The box plots display the data distribution with the following elements: the central line represents the median (50th percentile); the box bounds indicate the interquartile range (25th and 75th percentiles); the whiskers extend to the minima and maxima within 1.5 times the interquartile range; and any points beyond the whiskers represent outliers. Asterisks indicate the statistically significant associations in the validation set: one-sided one-sample t-test or Wilcoxon test, depending on the data distribution; Bonferroni correction for multiple comparisons: p-value < 0.0042. 5HT1aR serotonin receptor 1a, 5HT1bR serotonin receptor 1b, 5HT2aR serotonin receptor 2a, 5HT4R serotonin receptor 4, 5HT6R serotonin receptor 6, 5HTT serotonin transporter, alpha4beta2R acetylcholine receptor alpha4beta2, D1R dopamine receptor 1, D2R dopamine receptor 2, DAT dopamine transporter, M1R, muscarinic 1 receptor, NAT noradrenaline transporter, VAChT acetylcholine vesicular transporter. Source data are provided as a Source Data file.
