Fig. 4: Kinetic analysis of state transitions during dAsCas12a R-loop formation.
From: Dynamic basis of supercoiling-dependent DNA interrogation by Cas12a via R-loop intermediates
(A–D) Analysis as in Fig. 3B–H, applying the model shown in Fig. 3A to measurements of dAsCas12a. Linear fits to lnK plots show trends in the expected direction except for the I1-I2 transitions in (B) (fit not shown; discussed in text) and (D). All error bars represent standard errors (see Methods). See Supplementary Table 2 for trace statistics. Source data are provided for this figure.
