Fig. 5: Comparison of gene-specific Loss-of-Function Observed/Expected Upper Bound Fraction (LOEUF) scores derived from LoF and DoS variant sets. | Nature Communications

Fig. 5: Comparison of gene-specific Loss-of-Function Observed/Expected Upper Bound Fraction (LOEUF) scores derived from LoF and DoS variant sets.

From: Functionally constrained human proteins are less prone to mutational instability from single amino acid substitutions

Fig. 5

a Density plot of the comparison of LOEUF scores between those calculated with pLoF and DoS variation, where the colours from blue to red represent the density of points for individual genes by pLoF and DoS LOEUF measures, and histograms in red to the top and right show the distribution of values of LOUEF for DoS and pLoF variation, respectively, and (b) a heatmap of observed gene counts by LOEUF decile bin, allowing comparison of gene membership of each grouping by LOEUF scores, calculated from pLoF and DoS variation. Source data are provided as a Source Data file.

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