Fig. 5: Structural pathological analysis of the KOGG complex.
From: The structural basis for the human procollagen lysine hydroxylation and dual-glycosylation
a The pathogenic mutations mapping on the KOGG complex. The KOGG/UDP-Gal was depicted as a cartoon model. On protomers LH3B and ColGalT1V, the disease-associated mutation sites were highlighted as stick models colored in red for those reported in human clinic cases, in yellow for mutation sites in the ClinVar database with potential pathogenicity, and in green for two mutations identified in mice (plod3ugli and colgalt1fosse). The substrates bound were shown as surface model. The protomers LH3A and ColGalT1U were set to transparent to facilitate observation. b The enlarged views on enzymatic sites and LH3-ColGalT1 interface of KOGG complex.
