Table 1 Baseline characteristics in intention-to-treat analysis set

From: Edaravone dexborneol for ischemic stroke with sufficient recanalization after thrombectomy: a randomized phase II trial

Characteristics

ED group (n = 97)

Control group (n = 103)

Age, mean (SD), years

63.61 (10.75)

63.31 (10.84)

Gender, No. (%)

 Male

71 (73.2)

74 (71.8)

 Female

26 (26.8)

29 (28.2)

Weight, mean (SD), kga

71.05 (10.81)

71.12 (12.32)

BMI, mean (SD), kg/m2a

24.64 (2.81)

25.12 (3.77)

Medical History, n (%)b

 Previous ischemic stroke

18 (18.6)

21 (20.4)

 Hypertension

43 (44.3)

56 (54.4)

 Hyperlipidemia

2 (2.1)

1 (1.0)

 Diabetes

18 (18.6)

17 (16.5)

 Cardiac disease

14 (14.4)

18 (17.5)

 Atrial fibrillation

24 (24.7)

19 (18.4)

Medications, n (%)

 Antihypertensive drugs

31 (32.0)

30 (29.1)

 Statin or other lipid-lowering drug

7 (7.2)

4 (3.9)

 Aspirin or other antiplatelet drug

7 (7.2)

9 (8.7)

 Anticoagulation drug

10 (10.3)

7 (6.8)

Current smoker, No./total (%)

37/96 (38.5)

30/103 (29.1)

Current drinker, No./total (%)c

20/97 (20.6)

19/102 (18.6)

Baseline breath, median (IQR), /min

18 (18−18)

18 (18−18)

Baseline HR, median (IQR), /min

70 (61–86)

73 (61–82)

Blood pressure at baseline, mean (SD), mm Hg

 Systolic

141.8 (23.)

143.1 (25.1)

 Diastolic

83.2 (14.0)

82.9 (15.6)

Baseline blood glucose, median (IQR)d

7.30 (6.07–8.64)

7.37 (6.12–8.83)

Baseline ASPECTS score, median (IQR)e

8 (7–9)

8 (7–9)

Baseline NIHSS score, median (IQR)f

14 (10−17)

14 (11−18)

Pre-stroke score on the modified Rankin Scale (mRS), n (%)g

 mRS 0

89 (91.8)

90 (87.4)

 mRS 1

8 (8.2)

13 (12.6)

Median duration, median (IQR), min

 Onset to punctureh

312 (242–386)

319 (246–395)

 Onset to recanalization

383 (282–458)

386 (324–460)

 Groin puncture to recanalizationh

56 (40–87)

65 (44–99)

 Onset to randomization

421 (317–499)

422 (360–500)

Cause of large-vessel occlusion, n (%)

 Intracranial atherosclerosis

32 (33.0)

30 (29.1)

Extracranial atherosclerosis

23 (23.7)

31 (30.1)

Cardioembolism

36 (37.1)

36 (35.0)

Other cause

6 (6.2)

6 (5.8)

Intravenous alteplase, n (%)i

24 (24.7)

28 (27.2)

mTICI score at the end of the procedure, n (%)

2b

15 (15.5)

24 (23.3)

2c

2 (2.1)

5 (4.9)

3

80 (82.5)

74 (71.8)

Location of responsible vessel, n (%)

MCA-M1

47 (48.5)

51 (49.5)

MCA-M2

3 (3.1)

2 (1.9)

ICA

41 (42.3)

31 (32.0)

MCA-M1 + ICA

16 (16.5)

9 (8.7)

Cerebral collateral circulation grade, n (%)j

0

21 (24.1)

27 (27.8)

1

19 (21.8)

15 (15.5)

2

25 (28.7)

24 (24.7)

3

13 (14.9)

20 (20.6)

4

9 (10.3)

11 (11.3)

Recanalization during day time, n (%)k

71 (73.2)

77 (74.8)

  1. Data are No. (%) or No./total (%), mean (SD), or median (IQR).
  2. ED edaravone dexborneol, BMI body mass index, HR heart rate, NIHSS National Institutes of Health Stroke Scale, ASPECTS Alberta Stroke Program Early CT Score, mTICI modified thrombolysis in cerebral infarction, ICA internal carotid artery, MCA middle cerebral artery.
  3. aData missing for 3 participants for weight and BMI.
  4. bComorbidities based on family or patient report.
  5. cCurrently drinks alcohol means consuming alcohol at least once a week within 1 year prior to the onset of the disease.
  6. dData missing for 5 participants for blood-glucose at baseline.
  7. eASPECTS scores determine extent of ischemic tissue based on CT imaging. Scores range from 0 to 10 with higher scores indicating less infarct volume. Data missing for 5 participants for ASPECTS score at baseline.
  8. fScores on National Institutes of Health Scale (NIHSS) range from 0 to 42, with higher scores indicating more severe neurologic deficit; A mean NIHSS of 8–9 means moderate neurological deficit.
  9. gScores on the modified Rankin Scale (mRS) of functional disability range from 0 (no symptoms) to 6 (death).
  10. hData missing for 2 participants for time from onset to puncture and groin puncture to recanalization.
  11. iDefined as half or more than standard alteplase dose (0.9 mg/kg).
  12. jThe ASITN/SIR collateral circulation assessment system based on DSA examination. Grades range from 0 to 4 with higher grades indicating better collateral circulation. Grade 0−1 indicates poor collateral circulation; Grade 2 indicates moderate collateral circulation; and Grade 3–4 indicates better collateral circulation. Data missing for 10 participants for cerebral collateral circulation grade.
  13. kDay time referred to the time from 7 AM to 10 PM31.
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