Table 2 Genes of interest that are differentially expressed between triclabendazole-sensitive and -resistant Fasciola hepatica without and in response to triclabendazole treatment

From: Independent origins and non-parallel selection signatures of triclabendazole resistance in Fasciola hepatica

Gene ID

Description

Untreated

Log2 FC

FDR-adjusted P value

TCBZ-S

Log2 FC

FDR-adjusted P value

Higher in TCBZ-R

Lower in TCBZ-R

Higher with TCBZ treatment

Lower with TCBZ treatment

Maker-scaffold10x_1074_pilon-snap-gene-0.107

Alpha-tubulin

Y

-

2.30

3.4 × 10−17

-

-

−1.11

0.049

Maker-scaffold10x_13_pilon-snap-gene-2.125

Alpha-tubulin

Y

-

2.14

5.8 × 10−9

-

Y

−2.47

1.1 × 10−4

Maker-scaffold10x_13_pilon-snap-gene-2.129

Alpha-tubulin

Y

-

1.94

1.6 × 10−9

-

Y

−2.08

1.9 × 10−4

Maker-scaffold10x_1444_pilon-snap-gene-0.40

Alpha-tubulin

Y

-

1.17

4.6 × 10−5

-

-

−1.42

0.017

Maker-scaffold10x_45_pilon-snap-gene-0.45

Alpha-tubulin

Y

-

1.74

3.4 × 10−7

-

Y

−2.31

4.0 × 10−6

Maker-scaffold10x_592_pilon-snap-gene-0.21

Alpha-tubulin

Y

-

1.87

5.7 × 10−11

-

-

−1.51

9.7 × 10−3

Maker-scaffold10x_680_pilon-snap-gene-0.21

Alpha-tubulin

Y

-

1.30

1.7 × 10−5

-

-

−0.99

0.12

Maker-scaffold10x_809_pilon-snap-gene-0.10

Alpha-tubulin

Y

-

1.69

1.7 × 10−8

-

-

−1.78

1.3 × 10−3

Maker-scaffold10x_944_pilon-snap-gene-0.44

Alpha-tubulin

Y

-

2.40

9.5 × 10−21

-

-

−1.28

0.036

Snap_masked-scaffold10x_1189_pilon-processed-gene-0.77

Alpha-tubulin

Y

-

2.36

1.0 × 10−11

-

-

−3.25

1.8 × 10−3

Maker-scaffold10x_1708_pilon-snap-gene-0.5

Cytosolic carboxypeptidas × 10-like protein 5

Y

-

1.26

1.3 × 10−5

-

-

−0.86

0.13

Maker-scaffold10x_1084_pilon-snap-gene-0.149

Delta-tubulin

-

-

0.24

0.79

-

Y

−2.90

4.6 × 10−4

Maker-scaffold10x_486_pilon-snap-gene-0.86

EB1 C-terminal domain-containing protein

Y

-

2.77

8.5 × 10−18

-

Y

−1.94

6.5 × 10−4

Maker-scaffold10x_44_pilon-snap-gene-0.4

EGF-like domain-containing protein

Y

-

2.77

2.1 × 10−11

-

-

−1.53

0.16

Maker-scaffold10x_157_pilon-snap-gene-0.185

EGF-like domain-containing protein

Y

-

2.37

2.0 × 10−14

-

-

−1.74

0.046

Maker-scaffold10x_157_pilon-snap-gene-0.196

EGF-like domain-containing protein

Y

-

1.94

2.7 × 10−6

-

-

−2.04

0.035

Maker-scaffold10x_206_pilon-snap-gene-0.64

IQ motif, EF-hand binding site

Y

-

3.50

1.2 × 10−37

-

-

−0.99

0.13

Maker-scaffold10x_1309_pilon-snap-gene-0.85

Mitogen-activated protein kinase

-

-

0.51

0.24

Y

-

1.20

2.2 × 10−6

Maker-scaffold10x_559_pilon-snap-gene-0.27

Tubulin monoglycylase

Y

-

1.63

8.0 × 10−11

-

-

0.16

0.87

Maker-scaffold10x_61_pilon-snap-gene-0.52

Tubulin polyglutamylase

Y

-

1.76

9.1 × 10−9

-

-

−1.30

1.7 × 10−3

Maker-scaffold10x_234_pilon-augustus-gene-0.64

Tubulin polyglutamylase

Y

-

1.22

1.1 × 10−6

-

-

0.37

0.57

Maker-scaffold10x_242_pilon-snap-gene-0.27

Tubulin polyglutamylase

Y

-

1.44

8.3 × 10−6

-

-

−0.86

0.23

Maker-scaffold10x_383_pilon-snap-gene-1.0

Tubulin polyglutamylase

Y

-

1.65

1.2 × 10−9

-

-

−0.92

0.19

Maker-scaffold10x_483_pilon-snap-gene-0.117

Tubulin polyglutamylase

Y

-

1.51

9.3 × 10−5

-

-

−0.22

0.69

Maker-scaffold10x_908_pilon-snap-gene-1.169

Tubulin polyglutamylase

Y

-

1.60

2.7 × 10−6

-

-

−0.87

0.18

Maker-scaffold10x_1306_pilon-snap-gene-0.14

Tubulin polyglutamylase

Y

-

1.74

1.7 × 10−4

-

-

−2.06

0.065

Maker-scaffold10x_2067_pilon-augustus-gene-0.6

Tubulin polyglutamylase

Y

-

1.57

2.9 × 10−7

-

-

−1.11

0.032

Maker-scaffold10x_66_pilon-snap-gene-0.15

Ubiquitin carboxyl-terminal hydrolase

Y

-

1.07

4.0 × 10−4

Y

-

1.56

6.3 × 10−6

Maker-scaffold10x_73_pilon-snap-gene-0.14

Vasohibin-like protein

Y

-

2.07

1.7 × 10−10

-

Y

−2.70

8.5 × 10−5

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