Fig. 6: Increase in oxidative phosphorylation upon infection with C. albicans for kidney cell types in Il1r1-/- mice. | Nature Communications

Fig. 6: Increase in oxidative phosphorylation upon infection with C. albicans for kidney cell types in Il1r1-/- mice.

From: IL-1 protects from fatal systemic candidiasis in mice by inhibiting oxidative phosphorylation and hypoxia

Fig. 6

A Combined celltype specific Metascape ontology analysis for Il1r1-/- (right) and Il1r1+/- (left) based on differentially expressed genes (adj. p < 0.05) for infected (top) versus naive (bottom) conditions. Statistical test: two-sided Wilcoxon rank sum test followed by Bonferroni p-value adjustment. B Differentially active (adj. p-value < 0.1) signaling pathways for Il1r1-/- infected versus Il1r1+ /- infected. Statistical test: two-sided Wilcoxon rank sum test followed by Bonferroni p-value adjustment. C UCell enrichment scores for oxidative phosphorylation geneset signature. D, E Heatmaps showing expression of selected genes D from glycolysis pathway (mmu00010) and E from mitochondrial proteins per condition and cell type.

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