Fig. 6: Uterine epithelial deletion of Foxa2 impairs GE_4 differentiation.
From: Foxa2-dependent uterine glandular cell differentiation is essential for successful implantation
a Violin plots of GE_4 specific markers Lif and Prss29. b, c FISH of Lif and Prss29 in Foxa2f/f Ltf+/+ and Foxa2f/f LtfCre/+ females on day 4 of pregnancy. Areas within white boxes are presented in a higher magnification. Signals of Lif and Prss29 are detected in glands at the antimesometrial ends (arrows), but not in the glands close to luminal epithelia (arrowheads). Images presented are representative of three independent experiments. d Violin plots and FISH of pan-glandular markers Aqp5 and Wfdc15b in Foxa2f/f Ltf+/+ and Foxa2f/f LtfCre/+ females on day 4 of pregnancy. Epithelial cells are stained with CK8. Scale bars, 200 μm. le luminal epithelium, ge glandular epithelium, s stroma, M mesometrial pole, AM antimesometrial pole. Images presented are representative of three independent experiments.
