Fig. 7: GE_4 differentiation is independent of estrogen secretion on day 4.
From: Foxa2-dependent uterine glandular cell differentiation is essential for successful implantation
a. The scheme of an ovariectomized mouse model for panels b and c. Created in BioRender. Li, B. (2025) https://BioRender.com/v89y654. b, c FISH of Lif and Prss29 in intact and ovariectomized Foxa2f/f Ltf+/+ females on day 4 of pregnancy. Glandular epithelia are stained with FOXA2. Scale bars, 200 μm. Images presented are representative of three independent experiments. d FISH of Prss29 in Foxa2f/f Ltf+/+ and Foxa2f/f LtfCre/+ females in the evening of day 3 of pregnancy. Scale bar, 200 μm. Epithelial cells are stained with CK8. Images presented are representative of three independent experiments. Times of tissue collection are indicated on top of each panel. le, luminal epithelium; ge, glandular epithelium; s, stroma; M, mesometrial pole, AM, antimesometrial pole.
