Fig. 8: Prss29 + GE_4 group produces LIF in response to estrogen stimulation.
From: Foxa2-dependent uterine glandular cell differentiation is essential for successful implantation
a The scheme of an ovariectomized mouse model used in panels b and c. Created in BioRender. Li, B. (2025) https://BioRender.com/v89y654. b, c FISH of Prss29 and Lif in ovariectomized wild type females on day 2, 3 and 4 of pregnancy. Uterine tissues collected from intact wild type females at 10am on day 4 of pregnancy serve as positive controls. Scale bars, 200 μm. le luminal epithelium, ge glandular epithelium, s stroma, M mesometrial pole, AM antimesometrial pole. Images presented are representative of three independent experiments. d A proposed scheme of FOXA2-mediated glands differentiation in pre-implantation stage. Glands enter transitional phase to acquire the ability to secret LIF in response to estrogen stimulation. Created in BioRender. Li, B. (2025) https://BioRender.com/v89y654.
