Fig. 10: PVIN targeting drug therapy reproduces rehabilitation effects. | Nature Communications

Fig. 10: PVIN targeting drug therapy reproduces rehabilitation effects.

From: Parvalbumin interneurons regulate rehabilitation-induced functional recovery after stroke and identify a rehabilitation drug

Fig. 10

a Timeline and procedure for the drug administration of AUT00201 (‘AUT’, 20 mg/kg p.o.) or DLL-920 (‘DDL’, 10 mg/kg p.o.) and behavioral test. b Ratio of Zif268 positive PV interneurons (Left, F (2, 12) = 4.332, P = 0.0383) and density of Zif268 positive cells (right, F (2, 12) = 0.1324, P = 0.8773). One-way ANOVA, Tukey’s multiple comparisons test. n = 5. c Normalized motor performance in the pasta matrix test. Two-way repeated measure ANOVA, time by group, F (15, 189) = 3.890, P < 0.0001. *P < 0.05, **P < 0.01: Sham + vehicle vs Stroke + Vehicle, #P < 0.05, ##P < 0.01: Sham + vehicle vs Stroke + AUT, ++P < 0.01: Sham + vehicle vs Stroke + DDL, & &P < 0.01: Stroke + vehicle vs Stroke + DDL, Sidak’s multiple comparison test. d Functional recovery from day 3 to day 14. Two-tailed paired t-test for comparisons of 3 d and 14 d. One-way ANOVA and Tukey’s multiple comparison for comparisons of functional gains. F (2, 28) = 8.967, P = 0.0010. **P < 0.01, ****P < 0.0001. c, d n = 12 (Sham+Vehicle), 12 (Sham+AUT), 14 (Sham+DDL), 8 (Stroke+Vehicle), 12 (Stroke+AUT), 11 (Stroke+DDL). Data are presented as means ± sem.

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