Fig. 6: PV interneuron activation is necessary for recovery. | Nature Communications

Fig. 6: PV interneuron activation is necessary for recovery.

From: Parvalbumin interneurons regulate rehabilitation-induced functional recovery after stroke and identify a rehabilitation drug

Fig. 6

a Timeline, virus vectors, and injection sites in the chronic chemogenetic inhibition targeting PV interneurons. b Procedure for rehabilitation with chemogenetic inhibition. c Millet seed consumption with 2-h rehabilitation. n = 6. d, e Motor performance in the skilled reaching test (d time by group, F (6, 68) = 7.887, P < 0.0001) and the grid walk test (e time by group, F (6, 68) = 19.69, P < 0.0001). Two-way repeated measure ANOVA: Stroke + Rehab/mCherry vs Stroke + Rehab/hM4D(Gi), Sidak’s multiple comparison test. f, g Functional recovery by rehabilitation in the skilled reaching test (f) and the grid walk test (g). Two-tailed paired t-test. (d–g) n = 9 (Sham/mCherry), 8 (Sham/hM4D), 10 (Stroke+Rehab/mCherry) or 11 (Stroke+Rehab/hM4D). All data are presented as means ± sem. *P < 0.05, **P < 0.01, ***P < 0.001. (a, b) Created in BioRender127.

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