Fig. 9: Gamma oscillation in the stroke mouse model and human stroke patients. | Nature Communications

Fig. 9: Gamma oscillation in the stroke mouse model and human stroke patients.

From: Parvalbumin interneurons regulate rehabilitation-induced functional recovery after stroke and identify a rehabilitation drug

Fig. 9

a Electrode placement and timeline for the EEG recording. b Representative LFP traces in stroke animals. c Normalized power spectra of network oscillation in ipsilesional premotor cortex in awake period mice 21 days after the stroke (means ± sem). The orange rectangle indicates the lower gamma frequency band. d Normalized spectrum power change in low gamma frequency. Mixed-effects model, time by group, F (10, 62) = 11.87, P < 0.0001. *P < 0.05, ***P < 0.001, ****P < 0.0001: Sham vs Stroke, ++ P < 0.01, ++++ P < 0.0001: Sham vs Stroke + Rehab, ## P < 0.01: Stroke vs Stroke + Rehab, Tukey’s multiple comparisons test. Two-sided. Tukey’s HSD correction for multiple comparison. n = 4 (Sham), 7 (Stroke) or 5 (Stroke+Rehab). e Illustration of human EEG. f Arm motor Fugl-Meyer (FM) score after stroke. g Correlation matrix of the FM score and the relative gamma power during the recovery period (V3-5) in the ipsi (i) and contralesional (c) motor related areas. M1: primary motor area, PMD: dorsal premotor area, SMA: supplementary motor area in moderate to severe stroke patients (V1 FM < 46). h Correlation between the FM score and the normalized gamma power. Spearman correlation, two-sided (n = 25, r = 0.443, P = 0.026). e Created in BioRender127.

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