Fig. 6: Correlation analysis of percent power change from baseline with MDS-UPDRS scores and LEDD dosage following TUS protocols. | Nature Communications

Fig. 6: Correlation analysis of percent power change from baseline with MDS-UPDRS scores and LEDD dosage following TUS protocols.

From: Individualized non-invasive deep brain stimulation of the basal ganglia using transcranial ultrasound stimulation

Fig. 6

This figure displays scatter plots examining the relationship between percent power change from baseline (n = 18 hemispheres) and clinical as well as pharmacological variables across different TUS protocols. Each panel presents Pearson correlation values (r) and associated significance levels (p-values), analyzing the potential link between changes in spectral power and either MDS-UPDRS scores or LEDD (Levodopa Equivalent Daily Dose) in milligrams (mg). A, B show the correlations for tbTUS (theta burst TUS) with Passive and Active Sham respectively, while C, D illustrate the same for 10 Hz TUS with Passive and Active Sham, respectively. The left graphs of each panel correspond to correlations with MDS-UPDRS, and the right graphs with LEDD dosage. Notably, significant correlations are observed in the right graphs of (A, B, C), suggesting a relationship between LEDD dosage and spectral power change in these conditions. The shaded areas around the dotted line represent the 95% confidence intervals for the regression estimates.

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