Fig. 4: Regulatory network model for primed state pluripotency.
From: The regulatory architecture of the primed pluripotent cell state
a Regulatory network of primed state pluripotency with 120 nodes and 1273 unidirectional edges. Only significant effects (FDR < 10−10, 2-tailed aREA test) are included. The size of each node is proportional to its Regularized Out-Degree (ROD) score; colors indicate community assignment (strong, FDR < 0.01; weak, 0.01 < FDR < 0.1; unassigned FDR > 0.1). Six outlier MRs showing the highest ROD scores (Speakers) are highlighted. b Heatmap showing the effect of silencing each MR on the activity of all other MRs. The silenced MRs are represented by the columns, and the rows report activity changes for the indicated proteins. The 77 MRs (76 strong community members and Utf1) are grouped by their community membership. The color scale indicates statistical significance (-log10(FDR), 2-tailed aREA test) for each MR protein differential activity; only significant changes in protein activity (FDR < 10−10) are shown.
