Fig. 2: Receptor Ligand Interactions in the Orthosteric Pocket for Tryptamine and Phenethylamines.
From: The structural diversity of psychedelic drug actions revealed
A–C Modeled interactions are shown by the dotted yellow line and based on the modeled distances from the cryo-EM structures. Each residue for the receptor is labeled by the Ballesteros–Weinstein (BW) numbering scheme. Each panel exhibits the structures: (A) 5-HT, (B) Psilocin, and (C) DMT. D, E Overlay of either 5-HT and Psilocin (D) or 5-HT and DMT (E). F, G Showcase the electrostatic interactions of either LSD (F) or BOL (G) shown in the dotted yellow line. H BOL and selected residues at the bottom of the orthosteric pocket shown as vdW spheres. I Overlay of 5-HT2AR with either LSD or BOL from this work, 5-HT2BR with LSD (PDB: 7SRQ), and D2R LSD (PDB: 9BS9 (unpublished)).
