Fig. 2: Interactions between ETB and calcineurin. | Nature Communications

Fig. 2: Interactions between ETB and calcineurin.

From: Structure of a lasso peptide bound ETB receptor provides insights into the mechanism of GPCR inverse agonism

Fig. 2

a Structural comparison of the crystal structure of the calcineurin-FKBP12 complex (PDB 1TCO) and the current apo ETB-CN-FKBP12 complex. b, c Close-up views of the N-terminus and C-terminus of calcineurin. d Electrostatic surface potentials of ETB and calcineurin in the apo-ETB-CN-FKBP12 complex. e Charged residues at the interface of ETB and calcineurin. f–h Structural comparison of the apo-ETB-CN-FKBP12 complex and the AF-predicted ETB-CN structure.

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