Fig. 3: Structural comparison of inactive ET_B structures.

a–c Superimposition of the apo ET_B-CN-FKBP12 complex and the apo-crystal structure of ET_B-mT4L (PDB 5GLI), viewed from the extracellular side (a) and the membrane plane (b and c). The mT4L and CN-B fusions into ICL3 are shown in (c).