Fig. 5: Structural comparison of the ETB receptors. | Nature Communications

Fig. 5: Structural comparison of the ETB receptors.

From: Structure of a lasso peptide bound ETB receptor provides insights into the mechanism of GPCR inverse agonism

Fig. 5

a–d Structural changes upon binding of ET-1 (a, PDB 8IY5), RES-701-3 (b), bosentan (c, PDB 5 × 93), and IRL2500 (d, PDB 6KIQ), focused on TM6. Apo state and compound-bound structures are colored gray and light-green, respectively. Black arrows indicate conformational changes upon drug binding.

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