Fig. 6: Oxidative stress inhibits human gut microbiota fermentation and promotes facultative anaerobic pathogens to bloom. | Nature Communications

Fig. 6: Oxidative stress inhibits human gut microbiota fermentation and promotes facultative anaerobic pathogens to bloom.

From: Sublethal systemic LPS in mice enables gut-luminal pathogens to bloom through oxygen species-mediated microbiota inhibition

Fig. 6

a–d An inoculation reactor containing immobilised faecal microbiota of an adult donor inoculated test reactors (TR1-4). TRs were inoculated with S. Tm at −12h to reach a density of 1 × 108 c.f.u. ml-1. 12 h post S. Tm inoculation, TRs were exposed to varying H2O2 concentrations 0 mM (TR1), 1.5 mM (TR2), 3 mM (TR3), 8 mM (TR4) (reactors n = 4). TR effluent was collected every 3 h to 12 h. L-glutamate, acetate, propionate, and butyrate concentrations in TR effluent post-H2O2 exposure (reactors n = 4). e S. Tm loads in TR effluent post-H2O2 exposure (reactors n = 4). f 16S rRNA gene sequencing family-level microbiota composition in TR effluent post-H2O2 exposure (reactors n = 4). Dashed lines indicate time of H2O2 exposure. Source data are provided in the Source Data file.

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