Fig. 8: Membrane fluidity modulates condensate affinity and membrane segment tension. | Nature Communications

Fig. 8: Membrane fluidity modulates condensate affinity and membrane segment tension.

From: Lipid packing and cholesterol content regulate membrane wetting and remodeling by biomolecular condensates

Fig. 8

a Affinity contrast as a function of fluidity fraction for all tested membrane systems in contact with glycinin condensates. The symbols indicate mean ± SD with n = 5 for the fluidity fraction determination, and n = 10 for the affinity contrast. The dashed line is just a guide to the eye. The insets illustrate that condensate affinity for the membrane increases as \(W\) decreases. b Intrinsic contact angle, \({\theta }_{e}^{{in}}\) for the same systems shown in (a). The symbols indicate mean ± SD with n = 5 for the fluidity fraction determination, and n = 10 for the intrinsic angle calculation. c Membrane tension for the \({ie}\) and \({ic}\) vesicle segments (respectively wetted by the protein-poor phase and by the condensate), as indicated in the sketch. Individual measurements are shown with small symbols and mean ± SD values are indicated with larger symbols (n = 7). Lines are a guide to the eye. All data were obtained for the previously defined working conditions. Source data are provided as a Source Data file.

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