Fig. 6: Cancer-associated phosphosites and differentially activated kinases identified from a pan-cancer analysis.
From: Deciphering the dark cancer phosphoproteome using machine-learned co-regulation of phosphosites
a Phosphosites with the most significant differential abundance between tumor and normal samples in the pan-cancer analysis (two-sided unpaired Wilcoxon Rank Sum test, with meta p-values calculated using the sumz method). These sites were illuminated using CoPheeKSA and CoPheeMap after identification. Yellow dot: unannotated sites with kinases predicted by CoPheeKSA. Purple dot: sites with known kinase. Green dot: unannotated sites mapped in CoPheeMap. b Differentially activated kinases identified from the pan-cancer analysis. The heatmap shows the numbers of substrates for each kinase in the ground-truth dataset and CoPheeKSA predictions, respectively. Kinases with a green box are those identified using the comprehensive KSA database but not by the ground-truth dataset. Source data are provided as a Source Data file.
