Fig. 7: Proposed model for tip growth under conditions of hyperosmotic stress. | Nature Communications

Fig. 7: Proposed model for tip growth under conditions of hyperosmotic stress.

From: The stomatin-like protein StlP organizes membrane microdomains to govern polar growth in filamentous actinobacteria under hyperosmotic stress

Fig. 7

StlP, a stomatin-like protein, undergoes oligomerization, creating an assembly on the membrane that facilitates the formation of microdomains. These microdomains induce local membrane fluidization and serve as a platform for coordinated cell wall synthesis, ensuring normal polar growth. In the absence of StlP (right panel), membrane fluidity diminishes in the tip region, coinciding with the diffusion of apical cellulose-like glycan and peptidoglycan synthesis foci, resulting in the loss of spatially confined cell wall synthesis. This weakens the cell wall, leading to the extrusion of cells with deficient walls. The black arrowhead points to a CWD cell that rebuilds its cell wall. Model created in BioRender. Claessen (2025) https://BioRender.com/p05m048.

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