Fig. 2: Lef attenuated cardiotoxicity in αPD1-treated melanoma mice. | Nature Communications

Fig. 2: Lef attenuated cardiotoxicity in αPD1-treated melanoma mice.

From: Microbiota-indole-3-propionic acid-heart axis mediates the protection of leflunomide against αPD1-induced cardiotoxicity in mice

Fig. 2

A Representative M-mode echocardiographic images of the left ventricle. Ejection fraction (EF) (B) and Fractional shortening (FS) (C) and Left ventricular end-diastolic internal diameter (LVIDd) (D) were detected in these groups (n = 8). 2D speckle-tracking echocardiography and strain analysis (E) and Average radial strain (ARS) (F) and Global longitudinal strain (GLS) (G) (n = 4). H Heart weight-to-body weight ratio (HW/BW) (n = 8). I, J Plasma biomarker assessments revealing levels of cardiac troponin T (cTnT) and creatine kinase-MB (CK-MB) (n = 6). K HE staining and quantification of cardiomyocyte cross-sectional area (n = 6). L Masson trichrome staining and quantification of cardiac fibrosis (n = 6). Data are shown as the mean ± SEM and analyzed using one-way ANOVA with post hoc tests.

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