Fig. 1: Overall structure of ligand-bound MCT8 homodimer.
From: Structural insights into thyroid hormone transporter MCT8
a Cryo-EM map and overall structure of MCT8. The two protomers of MCT8 are distinctly colored in violet and green, while lipids are depicted in yellow. MCT8 bound to silychristin was used. b Structure of MCT8 bound to silychristin. Silychristin is highlighted in brown in the cryo-EM map, with its chemical structure and density shown in the panel below. c Structure of MCT8 bound to triiodothyronine (T3). T3 is highlighted in green. The chemical structure and density of T3 are shown in the panel below. All density and structure figures were prepared using ChimeraX.
