Fig. 4: Inhibition of MCT8 by silychristin.
From: Structural insights into thyroid hormone transporter MCT8
a, b Interactions between MCT8 and silychristin. Key residues are shown as sticks. The yellow dashed lines indicate hydrogen bonds. c A schematic presentation of silychristin coordination by MCT8. d, e MST measurement of the binding affinities between MCT8 variants and silychristin. Fractions bound of MCT8 variants were normalized against those of WT protein. Three biological repeats were carried out in the experiment (mean ± SEM; n = 3; N.D: not detectable).
